Scientists in Australia uncover how lung cancer cells' 'personal lives' predict treatment response

Scientists in Australia have mapped the "neighborhoods" of lung cancer cells and found that cell metabolism plays a key role in determining how patients respond to immunotherapy.

Researchers from the University of Queensland's (UQ) Frazer Institute studied cell interactions at cellular resolution in non-small cell lung carcinoma, the most common form of lung cancer, to better understand why some patients don't respond to immunotherapy treatment, said a UQ statement on Wednesday.

Using machine-learning algorithms and computational approaches, the study, published in Nature Communications, examined how cells interact and metabolize glucose, which cancer cells thrive on, said Associate Professor Arutha Kulasinghe from UQ's Frazer Institute.

"We were able to dive deep into the complex nature of cells, basically looking at the cells' personal lives in the complex composition of a tumor, and found certain metabolic neighborhoods were associated with response and resistance to immunotherapy," Kulasinghe said.

Immunotherapy is costly and benefits only a minority of patients, he said, adding that "it's important to understand how to identify these patients, and those that might need combination or alternative therapies."

Lead author James Monkman from UQ's Frazer Institute said higher glucose uptake in cancer cells was associated with poorer outcomes.

"We know cancer cells love sugar, and we analyzed where glucose was being processed in the cells and where it wasn't," Monkman said. "You could have a region of a tumor processing glucose in a completely different way to another area of the tumor."

The next step is to develop targeted treatments, such as with metabolic inhibitors, to make immunotherapy more effective, and eventually enable precision medicine tailored to each patient's tumor, with plans to extend the approach to other cancers, the researchers said.