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They occur naturally but biochemists can make synthetic versions.
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Prof Howl and colleague Dr Sarah Jones first demonstrated that certain cell-penetrating peptides could smuggle themselves inside sperm cells, like a Trojan horse.
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Then they joined forces with IVF experts at Aveiro University in Portugal, who had identified the crucial protein responsible for putting the wiggle into sperm tails.
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The two universities created a bespoke peptide which turns that protein off.
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They tested the approach in the petri dish on bovine and human sperm, with similarly impressive results, and will soon publish their results.
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Prof Howl said they hoped to start live animal tests in two to three years, thanks in part to a 175,000 Portuguese grant.
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It typically takes three to five years to bring a new drug to market after animal trials, so the final product could be available as early as 2021. Prof Howl said it was too early to say if the end result would be a pill, a nasal spray or a sub-skin implant, but they were all possibilities.
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John Guillebaud, emeritus professor of family planning and reproductive health at University College, London, said a reversible male contraceptive would be of enormous benefit to many couples, such as those where the woman cannot take the Pill for medical reasons for instance due to migraine with aura or an increased risk of blood clots.
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